Furthermore, if the KD increases GABA levels in the brain, then such an effect is approximated by vigabatrin, an irreversible inhibitor of the degradative enzyme GABA-transaminase, as well as by tiagabine, a GABA re-uptake blocker that interferes with presnaptic GABA transporters (White et al., 2007). Yet, the anticonvulsant profile of the KD is distinct from that of vigabatrin and tiagabine (Hartman et al., 2007). The general approach of deriving another pill that enhances brain GABA levels may not be relevant or viable, since many seizure types seem to be exacerbated by agents that contribute to enhanced tonic inhibition, and extrasynaptic GABA receptors that mediate tonic inhibition are more sensitive to elevated ambient GABA concentrations (Sazgar & Bourgeois, 2005). Indeed, increased GABAergic inhibition in the cortex appears to underlie the mechanism of synchronization and seizure generation in two mouse models of autosomal dominant nocturnal frontal lobe epilepsy (Klassen et al, 2006)

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Resep Alpukat Panggang Keju Mozarella – Awal jalani diet Keto, nggak sengaja baca status fbnya mba Dita Nadia yang majang foto alpukat panggang yang menggiurkan.  Katanya menu ini menu sarapan orang luar sono. Wuih kayaknya enak banget, langsung ngiler. Tapi baru keingat, kan saya nggak punya oven, gimana manggangnya dong 😀 Langsung kepikiran pengen punya oven, …

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